5/17/2025
Last update
5/17/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.3
USERS' SCORE
Good
Based on 39 Reviews
8.2
Supplement Facts
Serving Size: 3 tablets
Serving Per Container: 83
Amount Per Serving
%DV
Calcium (as calcium carbonate, calcium gluconate, calcium citrate)
1,000 mg
77%
Magnesium (as magnesium oxide, magnesium gluconate, magnesium citrate)
400 mg
95%
Zinc (as zinc gluconate)
15 mg
136%
Sodium†
15 mg
<1%
Top Medical Research Studies
7
We investigated how choline magnesium trisalicylate (CMT) helps alleviate bone pain in patients with metastatic cancer. In a carefully designed study involving 26 participants, we compared CMT against a placebo in a crossover format, measuring pain relief at multiple intervals after dosing.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
Read More
7
We evaluated the effects of pamidronate therapy on children with osteogenesis imperfecta type III. Over the course of treatment, we saw reductions in bone pain, alongside a significant decrease in fracture incidence.
The therapy positively impacted children's daily activities and their overall mobility. Importantly, the treatment was found to be safe, although some patients experienced mild side effects like low calcium levels and a fever. Overall, our findings suggest that bisphosphonate therapy is beneficial for management in these young patients.
The therapy positively impacted children's daily activities and their overall mobility. Importantly, the treatment was found to be safe, although some patients experienced mild side effects like low calcium levels and a fever. Overall, our findings suggest that bisphosphonate therapy is beneficial for management in these young patients.
Read More
8
We explored the impact of calcium treatment on bone pain in patients who developed osteomalacia, a condition linked to intravenous iron infusions. Our focus was on a group of 13 patients diagnosed with this condition, who experienced low phosphate levels due to excess fibroblast growth factor 23 (iFGF23) after receiving ferric carboxymaltose (FCM) infusions.
After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.
Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.
After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.
Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.
Read More
Most Useful Reviews
9
Enhances bone strength
186 people found this helpful
FOR IMMUNITY AND HEART HEALTH! A reliable brand that truly works. Magnesium and calcium are vital for maintaining many biological processes. With high physical and mental stress, these trace elements are indispensable for my heart and skeletal muscles, compensating for deficiencies in bone and dental tissues. Calcium is involved in blood coagulation and muscle contractions. Magnesium supports heart muscle functioning and energy processes, while zinc is essential for intestinal cell function, bone growth, and my immune system.
Read More
9
Strengthened bones
38 people found this helpful
I purchased this to address my calcium and magnesium deficiency caused by an unbalanced diet. The symptoms included fragile nails and leg cramps. Almost immediately after starting, the cramps ceased, and my nails have grown much stronger. I take three tablets daily, and the large bottle offers excellent value as it lasts 2-3 months.
Read More
9
Reduced joint pain
6 people found this helpful
This drug was prescribed for my 14-year-old child in combination with other dietary supplements. After starting the supplement, the child began to grow intensively but faced some weight issues and joint pain. After two months, I've noticed that the joint pain has significantly diminished, and the child's sleep has also improved, likely due to magnesium. I recommend this dietary supplement, as it appears effective, especially with the prescribed dosage of two tablets per day. Best wishes for good health to everyone!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.3
- All Researches
8
We explored the impact of calcium treatment on bone pain in patients who developed osteomalacia, a condition linked to intravenous iron infusions. Our focus was on a group of 13 patients diagnosed with this condition, who experienced low phosphate levels due to excess fibroblast growth factor 23 (iFGF23) after receiving ferric carboxymaltose (FCM) infusions.
After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.
Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.
After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.
Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.
Read More
7
Promising drug delivery for osteoporosis
We developed a novel drug delivery system combining denosumab and magnesium within metal-organic frameworks to target osteoarthritis. The framework showed good potential for loaded drug release, delivering about 72% of denosumab in just 8 hours.
Additionally, it released magnesium ions, which are beneficial for bone formation. Our cytotoxicity tests demonstrated that the system is biocompatible and encourages cell growth over time. While our findings are promising for pain relief linked to osteoporosis, further studies are needed to confirm effectiveness in real-world scenarios.
Additionally, it released magnesium ions, which are beneficial for bone formation. Our cytotoxicity tests demonstrated that the system is biocompatible and encourages cell growth over time. While our findings are promising for pain relief linked to osteoporosis, further studies are needed to confirm effectiveness in real-world scenarios.
Read More
7
We evaluated the effects of pamidronate therapy on children with osteogenesis imperfecta type III. Over the course of treatment, we saw reductions in bone pain, alongside a significant decrease in fracture incidence.
The therapy positively impacted children's daily activities and their overall mobility. Importantly, the treatment was found to be safe, although some patients experienced mild side effects like low calcium levels and a fever. Overall, our findings suggest that bisphosphonate therapy is beneficial for management in these young patients.
The therapy positively impacted children's daily activities and their overall mobility. Importantly, the treatment was found to be safe, although some patients experienced mild side effects like low calcium levels and a fever. Overall, our findings suggest that bisphosphonate therapy is beneficial for management in these young patients.
Read More
7
We investigated how choline magnesium trisalicylate (CMT) helps alleviate bone pain in patients with metastatic cancer. In a carefully designed study involving 26 participants, we compared CMT against a placebo in a crossover format, measuring pain relief at multiple intervals after dosing.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
Read More
User Reviews
USERS' SCORE
Good
Based on 39 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Enhances bone strength
186 people found this helpful
FOR IMMUNITY AND HEART HEALTH! A reliable brand that truly works. Magnesium and calcium are vital for maintaining many biological processes. With high physical and mental stress, these trace elements are indispensable for my heart and skeletal muscles, compensating for deficiencies in bone and dental tissues. Calcium is involved in blood coagulation and muscle contractions. Magnesium supports heart muscle functioning and energy processes, while zinc is essential for intestinal cell function, bone growth, and my immune system.
Read More
9
Strengthened bones
38 people found this helpful
I purchased this to address my calcium and magnesium deficiency caused by an unbalanced diet. The symptoms included fragile nails and leg cramps. Almost immediately after starting, the cramps ceased, and my nails have grown much stronger. I take three tablets daily, and the large bottle offers excellent value as it lasts 2-3 months.
Read More
9
Reduced joint pain
6 people found this helpful
This drug was prescribed for my 14-year-old child in combination with other dietary supplements. After starting the supplement, the child began to grow intensively but faced some weight issues and joint pain. After two months, I've noticed that the joint pain has significantly diminished, and the child's sleep has also improved, likely due to magnesium. I recommend this dietary supplement, as it appears effective, especially with the prescribed dosage of two tablets per day. Best wishes for good health to everyone!
Read More
9
Effective supplement
6 people found this helpful
Combined mineral supplements like calcium-magnesium-zinc are increasingly popular for enhancing bone density. Calcium, magnesium, and zinc strengthen bones in numerous ways, and I've found this Solgar supplement effective. The large, economical can lasts quite a while, though the tablets are somewhat large and hard to swallow. Overall, I recommend it for those pursuing better health.
Read More
9
Joint pain resolved
5 people found this helpful
I’ve noticed a significant difference since taking this calcium, along with ginkgo biloba and biotin. Previously, I felt broken in the mornings, but now I have energy. Unlike other supplements, this doesn't make me feel heavy in the stomach and has relieved my joint pains. The large container lasts a long time, making it good value.
Read More
Frequently Asked Questions
8
Reduces bone pain
16 people found this helpful
The result is evident! I started taking these because of bone pain in my legs. After about a month and a half, I noticed I could run without pain. Interestingly, my grey hair has begun to regain its colour. This calcium preparation is very effective, and I've already ordered a second jar. 👍🏼
9
Reduced joint pain
6 people found this helpful
This drug was prescribed for my 14-year-old child in combination with other dietary supplements. After starting the supplement, the child began to grow intensively but faced some weight issues and joint pain. After two months, I've noticed that the joint pain has significantly diminished, and the child's sleep has also improved, likely due to magnesium. I recommend this dietary supplement, as it appears effective, especially with the prescribed dosage of two tablets per day. Best wishes for good health to everyone!
9
Joint pain alleviated
4 people found this helpful
I can vouch for the wonderful composition of this calcium, magnesium, and zinc supplement. This is my second order, and it has successfully alleviated my joint pain.
9
Effective supplement
6 people found this helpful
Combined mineral supplements like calcium-magnesium-zinc are increasingly popular for enhancing bone density. Calcium, magnesium, and zinc strengthen bones in numerous ways, and I've found this Solgar supplement effective. The large, economical can lasts quite a while, though the tablets are somewhat large and hard to swallow. Overall, I recommend it for those pursuing better health.
9
Strengthened bones
38 people found this helpful
I purchased this to address my calcium and magnesium deficiency caused by an unbalanced diet. The symptoms included fragile nails and leg cramps. Almost immediately after starting, the cramps ceased, and my nails have grown much stronger. I take three tablets daily, and the large bottle offers excellent value as it lasts 2-3 months.
7.5
Improved muscle pain
2 people found this helpful
This is the best type of calcium I've tried, and it includes magnesium and zinc. I have noticed improvements in my joints and muscle pain has been alleviated. Additionally, there's been a noticeable enhancement in my hair, with reduced hair loss and increased energy levels. Highly recommend it!
7.5
Eliminates cramps
80 people found this helpful
I ordered this complex after giving birth due to weak nails and leg cramps. The formulation contains calcium, magnesium, and zinc, which work synergistically. I used to experience noticeable leg cramps but have not had any since taking this complex. My nails are no longer exfoliating, and my hair loss has significantly decreased. Magnesium enhances protein synthesis and hair structure, making this complex worthwhile. I highly recommend it!
9
Joint pain resolved
5 people found this helpful
I’ve noticed a significant difference since taking this calcium, along with ginkgo biloba and biotin. Previously, I felt broken in the mornings, but now I have energy. Unlike other supplements, this doesn't make me feel heavy in the stomach and has relieved my joint pains. The large container lasts a long time, making it good value.
7.5
Joint pain relief
3 people found this helpful
I purchased this stunning vitamin complex for my husband and me. After just a week, my husband’s joint pain and muscle cramps stopped, enhancing his energy levels. Personally, I feel more active and mobile, seamlessly doing yoga without fear of muscle strain. At 40, we both appreciate these positive changes and highly recommend them.
7
We investigated how choline magnesium trisalicylate (CMT) helps alleviate bone pain in patients with metastatic cancer. In a carefully designed study involving 26 participants, we compared CMT against a placebo in a crossover format, measuring pain relief at multiple intervals after dosing.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
7
Promising drug delivery for osteoporosis
We developed a novel drug delivery system combining denosumab and magnesium within metal-organic frameworks to target osteoarthritis. The framework showed good potential for loaded drug release, delivering about 72% of denosumab in just 8 hours.
Additionally, it released magnesium ions, which are beneficial for bone formation. Our cytotoxicity tests demonstrated that the system is biocompatible and encourages cell growth over time. While our findings are promising for pain relief linked to osteoporosis, further studies are needed to confirm effectiveness in real-world scenarios.
Additionally, it released magnesium ions, which are beneficial for bone formation. Our cytotoxicity tests demonstrated that the system is biocompatible and encourages cell growth over time. While our findings are promising for pain relief linked to osteoporosis, further studies are needed to confirm effectiveness in real-world scenarios.
8
We explored the impact of calcium treatment on bone pain in patients who developed osteomalacia, a condition linked to intravenous iron infusions. Our focus was on a group of 13 patients diagnosed with this condition, who experienced low phosphate levels due to excess fibroblast growth factor 23 (iFGF23) after receiving ferric carboxymaltose (FCM) infusions.
After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.
Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.
After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.
Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.
References
- von Brackel FN, Grambeck J, Barvencik F, Amling M, Oheim R. In-depth clinical characterization of intravenous iron infusion-induced hypophosphatemic osteomalacia and its resolution. JBMR Plus. 2024;8:ziae139. 10.1093/jbmrpl/ziae139
- Alsaikhan F, Mahmoud MZ, Suliman M. Synthesis and characterization of novel denosumab/magnesium-based metal organic frameworks nanocomposite prepared by ultrasonic route as drug delivery system for the treatment of osteoporosis. Front Bioeng Biotechnol. 2023;11:1153969. 10.3389/fbioe.2023.1153969
- Jakubowska-Pietkiewicz E, Chlebna-Sokół D. New trends in the treatment of osteogenesis imperfecta type III - own experience. Ortop Traumatol Rehabil. 2008;10:593.
- Johnson JR, Miller AJ. The efficacy of choline magnesium trisalicylate (CMT) in the management of metastatic bone pain: a pilot study. Palliat Med. 1994;8:129.
